2014
| ° | Live imaging of Xwnt5A-ROR2 complexes Wallkamm, V., Dörlich, R., Rahm, K., Klessing, T., Nienhaus, G.U., Wedlich, D., Gradl, D. (2014) PlosOne, accepted |
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| ° | CD44 regulates the Wnt pathway at the level of LRP6 Schmitt, M., Metzger, M., Gradl, D., Davidson, G., Orian-Rousseau, V. (2014) Cell Death Differ, doi: 10.1038/cdd.2014.156. [Epub ahead of print] |
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| ° | Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of wnt signaling activity. Kumar, S., Žigman, M., Patel, T.R., Trageser, B., Gross, J. C., Rahm, K., Boutros, M., Gradl, D., Steinbeisser, H., Holstein, T., Stetefeld, J. and Özbek, S. (2014) BMC Biol. 12:44 |
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| ° | Covalent and density-controlled surface immobilization of e-cadherin for adhesion force spectroscopy Fichtner D, Lorenz B, Engin S, Deichmann C, Oelkers M, Janshoff A, Menke A, Wedlich D, Franz CM (2014) PLoS One. 2014 Mar 27;9(3):e93123. doi: 10.1371 |
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| ° | Time-lapse X-ray phase-contrast microtomography for in vivo imaging and analysis of morphogenesis Moosmann, J., Ershov, A., Altapova, V., Baumbach, T., Prasad, M., LaBonne, C., Xiao, X., Kashef, J.* and Ralf Hofmann* (2014) Nature Protocols, 9(2):294-304. doi: 10.1038/nprot.2014. |
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| ° | Monensin Inhibits Canonical Wnt Signaling in Human Colorectal Cancer Cells and Suppresses Tumor Growth in Multiple Intestinal Neoplasia Mice Tumova, L., Pombinho, A.R., Vojtechova, M., Stancikova, J., Gradl, D., Krausova, M., Sloncova, E., Horazna, M., Kriz., V., Machonova, O., Jindrich, J., Zdrahal, Z., Bartunek, P., Korinek, V. (2014) Mol. Cancer Ther. 3(4):812-822 |
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| ° | The protocadherin PAPC is expressed in the CNC and can compensate for the loss of PCNS Schneider, M., Huang, C., Becker, S.F., Gradl, D., Wedlich, D.(2014) Genesis 52(2):120-126 |
2013
| ° | Cadherin-11 mediates contact inhibition of locomotion during Xenopus neural crest cell migration Becker, S.F., Mayor, R, Kashef, J. (2013) PLoS One, 8(12):e85717. doi: 10.1371/journal.pone.0085717. |
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| ° | Three-Dimensional Microscaffolds Exhibiting Spatially Resolved Surface Chemistry Richter B, Pauloehrl T, Kaschke J, Fichtner D, Fischer J, Greiner AM, Wedlich D, Wegener M, Delaittre G, Barner-Kowollik C, Bastmeyer M. (2013) Adv Mater. 2013 Sep 4. doi: 10.1002/adma.201302678. [Epub ahead of print] |
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| ° | Par3 controls neural crest migration by promoting microtubule catastrophe
during contact inhibition of locomotion Moore,R., Theveneau, E., Pozzi,S., Alexandre,P., Richardson,J., Merks, A., Parsons, M., Kashef, J., Linker,C. and Mayor, R. (2013) Development, 140(23):4763-75. doi: 10.1242/dev.098509 |
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| ° | Loss of Xenopus cadherin-11 leads to increased Wnt/β-catenin signaling and up-regulation of target genes c-myc and cyclin D1 in neural crest Koehler A., Schlupf J., Schneider M., Kraft B., Winter C., Kashef J. (2013) Developmental Biology, 383, 132-145 |
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| ° | X-ray phase-contrast in vivo microtomography probes new aspects of Xenopus gastrulation Moosmann J., Ershov A., Altapova V., Baumbach T., Prasad M.S., LaBonne C., Xiao X., Kashef J.*, Hofmann R.* (2013) Nature 497, 374–377 (16 May 2013) | doi:10.1038/nature12116 |
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| ° | Stimulated Emission Depletion-Based Raster Image Correlation Spectroscopy (STED-RICS) – A Versatile Method for Studying Biomolecular Dynamics in Live Cells. Hedde, P.N., Dörlich, R.M., Blomley, R., Gradl, D., Oppong, E., Cato, A.C.B. and Nienhaus, G.U. (2013) Nature Comm. Jun 27;4:2093. |
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| ° | Rediscovering the Double Friedel-Crafts Acylation: An Expedient Entry to Phenanthrene-9,10-diones Crosta, N., Müller, S., Gradl, D., Masters, K.-S. and Bräse, S. (2013) Synlett 24(8): 951-954. DOI: 10.1055/s-0032-1318481. |
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| ° | Quantitative Determination of Lateral Concentration and Depth Profile of Histidine-Tagged Recombinant Proteins by Grazing Incidence X-ray Fluorescence Körner A., Abuillan W., Deichmann C., Rossetti FF, Köhler A., Konovalov OV, Wedlich D., Tanaka M. (2013) J Phys Chem B. 2013 Apr 23. [Epub ahead of print] |
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| ° | SNAP-tag as a Tool for Surface Immobilization Engin S., Fichtner D., Wedlich D., Fruk L. (2013) Curr Pharm Des. 2013 Feb 14. [Epub ahead of print] |
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| ° | The vestibuloocular reflex of tadpoles (Xenopus laevis) after knock-down of the isthmus related transcription factor XTcf-4 Horn, E.R., El-Yamany, N.A. and Gradl, D. (2013) J Exp Biol.216(Pt 4), 733-741. |
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| ° | Cell Differentiation of Pluripotent Tissue Sheets Immobilized on Supported Membranes Displaying Cadherin-11 Alexander Körner, Christina Deichmann, Fernanda F. Rossetti, Almut Köhler, Oleg V. Konovalov, Doris Wedlich, Motomu Tanaka (2013) PLoS ONE02/2013; 8(2):e54749. doi: 10.1361/journal.pone.0054749. Epub 2013 Feb 12. |
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| ° | Synthesis of novel inhibitors blocking Wnt signaling downstream of b-Catenin Halbedl, S., Kratzer, M.-C. Rahm, K., Crosta, N. Masters, K.-C. Zippert, J., Bräse, S. and Gradl, D. (2013) FEBS Lett. 2013 Mar 1;587(5):522-7. doi: 10.1016/j.febslet.2013.01.034. Epub 2013 Jan 25. |
2012
| ° | Wnt11 and Fz7 reduce cell adhesion in convergent extension by sequestration of PAPC and C-cadherin Kraft, B., Berger, C., Wallkamm V., Steinbeisser H., Wedlich D. (2012) J Cell Biol. 2012 Aug 20;198(4):695-709. doi: 10.1083/jcb.201110076. |
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| ° | Microfluidic polycarbonate chip for long-term cell analyses Kreppenhofer K, Kim C, Schneider M, Herrmann D, Ahrens R, Kashef J, Gradl D, Wedlich D, Guber A. (2012) Biomed Tech (Berl). 2012 Aug 30. doi:pii: /j/bmte.2012.57.issue-s1-E/bmt-2012-4429/bmt-2012-4429.xml. 10.1515/bmt-2012-4429. [Epub ahead of print] |
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| ° | Giving the right tug for migration: Cadherins in tissue movements Becker, SF., Langhe, R., Huang, C., Wedlich, D. and Kashef, J. (2012) Archives of Biochemistry and Biophysics, (524): 30–42. |
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| ° | Diffusion- and convection-based activation of Wnt/β-catenin signaling in a gradient generating microfluidic chip Kim, C., Kreppenhofer, K., Kashef, J., Gradl, D., Herrmann, D., Schneider, M., Ahrens, R., Guber, A. and Wedlich, D. (2012) Lab Chip. 2012 Dec 21;12(24):5186-5194. doi: 10.1039/c2lc40172j. |
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| ° | Expression of the tetraspanin family members Tspan3, Tspan4, Tspan5 and Tspan7 during Xenopus laevis embryonic development Kashef, J., Diana, T., Oelgeschläger, M., Nazarenko, I. (2012) Gene Expression Patterns (2012) Science direct |
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| ° | Subfunctionalization and neofunctionalization of vertebrate Lef/Tcf transcription factors Klingel, S., Morath, I., Strietz, J., Menzel, K., Holstein, T.W., Gradl, D. (2012) Dev Biol. 2012 Aug 1;368(1):44-53. doi: 10.1016/j.ydbio.2012.05.012. Epub 2012 May 26. |
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| ° | Giving the right tug for migration: Cadherins in tissue movements Becker, SF., Langhe, R., Huang, C., Wedlich, D. and Kashef, J. (2012) Arch Biochem Biophys. 2012 Aug 1;524(1):30-42. doi: 10.1016/j.abb.2012.02.013. Epub 2012 Mar 3. Review |
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| ° | Live imaging of active fluorophore labelled Wnt proteins Holzer, T., Liffers, K., Rahm, K., Trageser, B., Ozbek, S., Gradl, D. (2012) FEBS Lett. 2012 Jun 4;586(11):1638-44. doi: 10.1016/j.febslet.2012.04.035. Epub 2012 Apr 26. |
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| ° | A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice Waaler, J., Machon, O., Tumova, L., Dinh, H., Korinek, V., Wilson, S.R., Paulsen, J.E., Pedersen, N.M., Eide, T.J., Machonova, O., Gradl, D., Voronkov, A., von Kries, J.P., Krauss, S. (2012) Cancer Res. 2012 Jun 1;72(11):2822-32. doi: 10.1158/0008-5472.CAN-11-3336. Epub 2012 Mar 22. |
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| ° | The p21-activated kinase Pak1 regulates induction and migration of the neural crest in Xenopus Bisson N, Wedlich D, Moss T. (2012) Cell Cycle. 2012 Apr 1;11(7):1316-24. doi: 10.4161/cc.19685. Epub 2012 Apr 1. |
2011
| ° | Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling Doubravska L, Krausova M, Gradl D, Vojtechova M, Tumova L, Lukas J, Valenta T, Pospichalova V, Fafilek B, Plachy J, Sebesta O, Korinek V. (2011) Cell Signal. 2011 May;23(5):837-48. doi: 10.1016/j.cellsig.2011.01.007. Epub 2011 Jan 16. |
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| ° | Functional conservation of Nematostella Wnts in canonical and noncanonical Wnt-signaling Rigo-Watermeier, T., Kraft, B., Ritthaler, M., Wallkamm, V., Holstein, T., Wedlich, D. (2011) Biol Open. 2012 Jan 15;1(1):43-51. doi: 10.1242/bio.2011021. Epub 2011 Nov 10. |
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| ° | Snail2 controls mesodermal BMP/Wnt induction of neural crest PShi J., Severson C., Yang J., Wedlich D., Klymkowsky MW. (2011) Development. 2011 Aug;138(15):3135-45. Epub 2011 Jun 29. |
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| ° | PAPC and the Wnt5a/Ror2 pathway control the invagination of the otic placode in Xenopus Jung, B., Koehler, A., Schambony, A., Wedlich D. (2011) BMC Developmental Biology 2011, 11:36doi:10.1186/1471-213X-11-36 |
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| ° | Bioconjugation of CdSe/ZnS Nanoparticles with SNAP tagged proteins Petershans, A., Wedlich, D., Fruk, L. (2011) Chem Commun (Camb). 2011 Oct 14;47(38):10671-3. doi: 10.1039/c1cc12874d. Epub 2011 Sep 2. |
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| ° | Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth Waaler, J., Machon O., von Kries, JP., Wilson, SR., Lundenes, E., Wedlich, D., Gradl, D., Paulsen, JE., Machonova, O., Dembinski, JL., Dinh, H., Krauss, S. (2011) Cancer Res. 2011 Jan 1;71(1):197-205 |
2010
| ° | TOF-SIMS Analysis of Structured Surfaces Biofunctionalized by a One-Step Coupling of a Spacer-Linked GRGDS peptide Petershans, A., Lyapin, A., Reichlmaier, S., Kalinina, S., Wedlich, D. and Gliemann, H. (2010) Journal of Colloid and Interface Science 341, 30–37 |
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| ° | Design of Chemically Activated Polymer Microwells by One-Step UV-Lithography for Stem Cell Adhesion Montero-Pancera, S.,Touillet, V., Petershans, A., Fichtner, D., Lyapin, A., Bruns, M., Schimmel, Th., Wedlich, D., Reichlmaier, S., Weidler, P., Gliemann, H. (2010) Langmuir. 26(3):2050-6 |
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| ° | Benzylguanine Thiol Self-Assembled Monolayers for the Immobilization of SNAP-tag Proteins on Microcontact-Printed Surface Structures Engin S, Trouillet V, Franz C. M., Welle A., Bruns M., and Wedlich D. (2010) Langmuir, 26(9), 6097-6101 |
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| ° | Prohibitin1 acts as a neural crest specifier in Xenopus development by repressing the transcription factor E2F1 Schneider M., Schambony A., Wedlich, D. (2010) Development 137(23):4073-81 |
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| ° | En2, Pax2/5 and Tcf-4 transcription factors cooperate in patterning the Xenopus brain Koenig SF, Brentle S, Hamdi K, Fichtner D, Wedlich D, Gradl D. (2010) Dev Biol.15;340(2):318-328 |
2009
| ° | Near-field optical study of protein transport kinetics at a single nuclear pore Herrmann M, Neuberth N, Wissler J, Pérez J, Gradl D, Naber A. (2009) Nano Lett. 2009 Sep;9(9):3330-6. |
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| ° | Cadherin-11 regulates protrusive activity in Xenpous cranial neural crest cells upstream of Trio and the small GTPases Kashef, J., Köhler, A., Kuriyama, S., Alfandari, D., Mayor, R. and Wedlich, D. (2009) Genes & Development 2009, 23: 1393-1398 |
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| ° | TOF-SIMS Analysis of Structured Surfaces Biofunctionalized by a One-Step Coupling of a Spacer-Linked GRGDS peptide Petershans A., Lyapin A., Reichlmaier S., Kalinina S., Wedlich D., Gliemannl H. (2009) Journal of Colloid and Interface Science, in press |
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| ° | The Extracellular Domain of Lrp5/6 Inhibits Noncanonical Wnt Signaling In Vivo Bryja V., Andersson E., Schambony A., Esner M., Bryjova L., Biris K., Hall A., Kraft B., Cajanek L., Yamaguchi T., Buckingham M. Arenas E.(2009) Molecular Biology of the Cell Vol. 20, 924–936, February 1, 2009 |
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| ° | Design of Chemically Activated Polymer Microwells by One-Step UV-Lithography for Stem Cell Adhesion Montero-Pancera, S.,Touillet, V., Petershans, A., Fichtner, D., Lyapin, A., Bruns, M., Schimmel, Th., Wedlich, D., Reichlmaier, S., Weidler, P., Gliemann, H. (2009) Langmuir, in press |
2008
| ° | beta-Arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways Vítězslav Bryja, Alexandra Schambony, Lukáš Čajánek, Isabel Dominguez, Ernest Arenas, Gunnar Schulte EMBO reports VOL 9, NO 12/ 2008, Seiten 1244-1250 |
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| ° | Regulated Adhesion as Driving Force in Gastrulation Hammerschmidt, M. and Wedlich, D. (2008) Development 135, 3625-41 |
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| ° | Cold-inducible RNA binding protein (CIRP), a novel XTcf-3 specific target gene regulates neural development in Xenopus. van Venrooy S, Fichtner D, Kunz M, Wedlich D, Gradl D. (2008) BMC Dev Biol. 8:77 |
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| ° | Isothiocyanate-functionalized RGD-peptides for tailoring cell-adhesive surface patterns Kalinina, S., Gliemann, H, López-García, M., Petershans, A., Auernheimer, J., Schimmel, T, Bruns,M., Schambony, A., Kessler, H. and Wedlich, D. (2008) Biomaterials.29(20):3004-13 |
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| ° | Polysialylated NCAM represses E-cadherin-mediated cell-cell adhesion in pancreatic tumor cells Schreiber, S., Giehl, K., Kastilan, C., Hasel, C., Mühlenhoff, M., Adler, G., Wedlich, D. and Menke, A. (2008) Gastroenterology.134(5):1555-66 |
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| ° | Autoregulation of XTcf-4 depends on a Lef/Tcf site on the XTcf-4 promoter Koenig, S.F., Lattanzio, R., Mansperger, K., Rupp, R.A.W., Wedlich, D. and Gradl, D. (2008) Genesis, 46, 81-86 |
2007
| ° | Wnt-5A/Ror2 regulate expression of XPAPC through an alternative non-canonical signaling pathway Schambony, A. and Wedlich, D. (2007) Dev. Cell. 12, 779-792 |
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| ° | Cell migration under control of Wnt singaling in the vertebrate embryo Koehler, A., Schambony, A. and Wedlich, D. (2007) In Sokol, S.Y. (ed) Wnt Signaling in Embryonic Development, Advances in Developmental Biology, Elsevier, Amsterdam, 159-201, ISBN: 978-0-444-52874-2 / ISBN10: 0-444-52874-1 |
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| ° | β-arrestin is a necessary component of wnt/β-catenin signalling in vitro and in vivo Vitezslav Bryja, Dietmar Gradl, Alexandra Schambony, Ernest Arenas and Gunnar Schulte Proc Natl Acad Sci U S A., 104, 6690-6695 |
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2006
| ° | Xenopus Cadherin-6 regulates growth and epithelial development of the retina Ruan, G., Wedlich, D. and Koehler, A. (2006) Mech Dev. 123, (12) 881-892 |
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| ° | Xenopus Teashirt1 regulates posterior identity in brain and cranial neural crest Koebernick, K., Kashef, J., Pieler, T. and Wedlich D. (2006) Dev Biol. 298, 312-326 |
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| ° | Hic-5 a novel regulator of Lef/Tcf activity modulates the crosstalk between Wnt-signalling and steroid receptor activity Ghogomu, S., van Venrooy, S., Ritthaler, M., Wedlich, D. and Gradl, D. (2006) J. Biol. Chem. 281, 1755-176 |
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| ° | Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines Tobias Pukrop, Florian Klemm, Thorsten Hagemann, Dietmar Gradl, Matthias Schulz, Sabine Siemes, Lorenz Trümper and Claudia Binder (2006) Proc.Natl.Acad.Sci USA 103, 5454-5459 |
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2005
| ° | Reduced production of spliceosomal U snRNPs as a major cause of cell death in SMN deficient cells Winkler, C., Eggert, C., Gradl, D., Meister, G., Giegerich, M., Wedlich, D., Laggerbauer, B., and Fischer, U. (2005) Genes Dev 19, 2320-2330. |
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| ° | TGF β-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN Vogelmann, R., Nguyen-Tat, M.D., Giehl, K., Adler, G., Wedlich, D., Menke A. J Cell Sci. 118,4901-4912 |
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| ° | Pontin and Reptin regulate cell proliferation in early Xenopus embryos in collaboration with c-Myc and Miz-1 Etard, Ch, Gradl, D., Kunz, M., Eilers, M. Wedlich, D. (2005) Mech. Dev. 122, 545-556 |
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2004
| ° | E- and N-cadherin differ with respect to their associated p120(ctn) isoforms and their ability to suppress invasive growth in pancreatic cancer cells Seidel B, Braeg S, Adler G, Wedlich D and Menke A. (2004) Oncogene 23: 5532-5542 |
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| ° | Autoregulation of Wnt signaling controls midbrain development Kunz, M., Herrmann, M., Wedlich, D. and Gradl, D (2004) Dev Biol. 273(2):390-401 |
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| ° | Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK Unterseher, F., Hefele, J.A., Giehl, K., De Robertis, E.M., Wedlich, D., Schambony, A. (2004) EMBO J. 23(16):3259-3269 |
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| ° | Cross-regulation of Wnt-signalling and cell adhesion Alexandra Schambony, Martin Kunz and Dietmar Gradl (2004) Differentiation. 72, 307-318. |
2003
| ° | A homologue of Cysteine Rich Secretory Proteins induces premature degradation of vitelline envelopes and hatching of Xenopus laevis embryo Schambony A., Hefele J.A., Gentzel M., Wilm M. and Wedlich D.(2003) Mech Dev.120: 937-48 |
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| ° | Prospects for tissue-specific analysis of gene expression in Xenopus embryos through laser-mediated microdissection of histological sections Imamichi, Y, Koebernick, K. and Wedlich, D. (2003) Pathol Res Pract 199(6):381-9 |
2002
| ° | Functional diversity of Xenopus LEF/TCF transcription factors relies on combinations of activating and repressing elements Gradl, D. König, A. and Wedlich, D. (2002) J. Biol. Chem. 277(16):14159-71 |
2001
| ° | Xenopus cadherin-11 restrains cranial neural crest migration and influences neural crest specification Borchers, A., David, R. and Wedlich D. (2001) Development 128: 3049-3060 |
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| ° | Xenopus eya 1 demarcates all neurogenic placodes as well as migrating hypaxial muscle precursors David R., Ahrens, K., Wedlich, D. and Schlosser, G. (2001) Mech. Dev. 103: 189-92 |
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| ° | Laser-mediated microdissection of paraffin sections from Xenopus embryos allows detection of tissue-specific expressed mRNAs Imamichi, Y, Lahr, G. and Wedlich, D. (2001) Dev. Genes Evol. 211: 361-366 |
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| ° | PCR-based RNA probes, a quick and sensitive method to improve whole mount embryo in situ hybridization David, R. and Wedlich, D. (2001) Biotechniques, 30: 769-72, 74 |
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| ° | Antagonistic regulation of convergent extension movements by Wnt/ß-catenin and Wnt/Ca2+ signalling Kühl, M., Geis, K. , Sheldahl, L.C., Pukrop, T, Moon, T. and Wedlich, D. (2001) Mech. Dev. 106: 61-76 |
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| ° | Downregulation of E-Cadherin Gene expression by Collagen Type I and Type III in Pancreatic Cancer Cell Lines Menke, A., Philippi, C., Vogelmann, R., Seidel, B., Lutz, M., Adler, G. and Wedlich, D. (2001) Cancer Research 61: 3508-3517 |
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| ° | Identification of two regulatory elements within the HMG-box transcription factor XTCF-4 Pukrop, T., Gradl, D.,. Henningfeld K.A., Knöchel, W., Wedlich, D. and Kühl, M. (2001) J Biol Chem. 276: 8968-78 |
Rezensionen
- Wedlich, D. (2002) The polarizing role of cell-adhesion molecules in early development. Curr. Opin. Cell Biol. 14: 563-568
- Köhler, A., Schambony A. and Wedlich D. (2006) Cell migration under control of Wnt-signaling in the vertebrate embryo. Advances in Developmental Biology in press
Bücher
Wedlich, D., Cell Migration in Development and Disease.
2004
Wiley-VCH
ISBN 3-527-30586-4
