Veröffentlichungen
2017
| ° | Thymosin 4 Improves Differentiation and Vascularization of EHTs. Ziegler, T., R. Hinkel, A. Stohr, T. Eschenhagen, K.-L. Laugwitz, F. le Noble, R. David, A. Hansen, and C. Kupatt (2017) Stem cells international, v. 2017, p. 6848271 |
| ° | Steerable Induction of the Thymosin beta4/MRTF-A Pathway via AAV-Based Overexpression Induces Therapeutic Neovascularization. Ziegler, T., M. Kraus, W. Husada, F. Gesenhues, Q. Jiang, O. Pinkenburg, T. Trenkwalder, K.-L. Laugwitz, F. le Noble, C. Weber, C. Kupatt, and R. Hinkel (2017) Human gene therapy |
| ° | Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization. Wild R, Klems A, Takamiya M, Hayashi Y, Strähle U, Ando K, Mochizuki N, van Impel A, Schulte-Merker S, Krueger J, Preau L, le Noble F (2017) Nature Communications. 8:13991. DOI: 10.1038/ncomms13991 |
2016
| ° | Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis. Lange C, Turrero Garcia M, Decimo I, Bifari F, Eelen G, Quaegebeur A, Boon R, Zhao H, Boeckx B, Chang J, Wu C, Le Noble F, Lambrechts D, Dewerchin M, Kuo CJ, Huttner WB, Carmeliet P. (2016) EMBO J. 2016 May 2;35(9):924-41. doi: 10.15252/embj.201592372. Epub 2016 Feb 8. PMID: 26856890 |
| ° | Regulation of distinct branches of the non-canonical Wnt-signaling network in Xenopus dorsal marginal zone explants. Wallkamm, V., Rahm, K., Schmoll, J., Kaufmann, L.T., Brinkmann, E., Schunk, J., Kraft, B., Wedlich, D., Gradl, D. (2016) BMC Biol. 14:55 |
| ° | Secreted frizzled-related protein 2 (sFRP2) redirects non-canonical Wnt signaling from Fz7 to Ror2 during vertebrate gastrulation. Brinkmann, E.M., Mattes, B., Kumar, R., Hagemann, A.I., Gradl, D., Scholpp,S., Steinbeisser, H., Kaufmann, L.T., Ozbek, S. (2016) J Biol Chem. 291(26):13730-42 |
| ° | A novel role for the tumour suppressor Nitrilase1 modulating the Wnt/β-catenin signalling pathway Mittag, S., Valenta, T., Weiske, J., Bloch, L., Klingel, S., Gradl, D., Wetzel, F., Chen, Iver Y. Petersen, I., Basler, K., and Huber, O. (2016) CellDiscovery 2, Article number: 15039 |
2015
| ° | The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane Loregger A, Grandl M, Mejías-Luque R, Allgäuer M, Degenhart K, Haselmann V, Oikonomou C, Hatzis P, Janssen KP, Nitsche U, Gradl D, van den Broek O, Destree O, Ulm K, Neumaier M, Kalali B, Jung A, Varela I, Schmid RM, Rad R, Busch DH, Gerhard M. (2015) Sci Signal. 8(393):ra90 |
| ° | Neural crest specification by prohibitin1 depends on transcriptional regulation of prl3 and vangl1 Deichmann C, Link M, Seyfang M, Knotz V, Gradl D, Wedlich D.(2015) Genesis. 53(10):627-639. |
| ° | CD44 regulates the Wnt pathway at the level of LRP6 Schmitt, M., Metzger, M., Gradl, D., Davidson, G., Orian-Rousseau, V. (2015) Cell Death Differ, 22(4):677-89 |
2014
| ° | MRTF-A controls vessels growth and maturation by increasing the expression of CCN1 and CCN2 Hinkel R., Trenkwalder T., Petersen, B., Husada W., Gesenhues F., Lee S., Hannappel E., Bock-Marquette I., Theisen D., Leitner L., Boekstegers P., Cierniewski C., Müller O., Le Noble F., Adams R., Weinl C., Nordheim A., Reichart B., Weber C., Olson E., Posern G., Deindl E., Niemann H., and Kupatt C. (2014) Nature Communications. 5:3970. DOI:10.1038/ncomms4970 |
| ° | Bone biology: Vessels of rejuvenation Le Noble F., and Le Noble J. (2014). Nature 507, 313-4. |
| ° | Live imaging of Xwnt5A-ROR2 complexes Wallkamm, V., Dörlich, R., Rahm, K., Klessing, T., Nienhaus, G.U., Wedlich, D., Gradl, D. (2014) PlosOne, 9(10):e109428 |
| ° | Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of wnt signaling activity. Kumar, S., Žigman, M., Patel, T.R., Trageser, B., Gross, J. C., Rahm, K., Boutros, M., Gradl, D., Steinbeisser, H., Holstein, T., Stetefeld, J. and Özbek, S. (2014) BMC Biol. 12:44 |
| ° | Monensin Inhibits Canonical Wnt Signaling in Human Colorectal Cancer Cells and Suppresses Tumor Growth in Multiple Intestinal Neoplasia Mice Tumova, L., Pombinho, A.R., Vojtechova, M., Stancikova, J., Gradl, D., Krausova, M., Sloncova, E., Horazna, M., Kriz., V., Machonova, O., Jindrich, J., Zdrahal, Z., Bartunek, P., Korinek, V. (2014) Mol. Cancer Ther. 3(4):812-822 |
| ° | The protocadherin PAPC is expressed in the CNC and can compensate for the loss of PCNS Schneider, M., Huang, C., Becker, S.F., Gradl, D., Wedlich, D.(2014) Genesis 52(2):120-126 |
2013
| ° | Circular RNAs are a large class of animal RNAs with regulatory potency Memczak S., Jens M., Elefsinioti A., Torti F., Krueger J., Rybak A., Maier L., Mackowiak S., Gregersen L., Munschauer M., Loewer A., Ziebold U., Landthaler M., Kocks C., Le Noble F., and Rajewsky N. (2013) Nature 495, 333-8 |
| ° | Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models Cristofaro B., Shi Y., Faria M., Suchting S., Leroyer A., Trindade A., Duarte A., Zovein A., Iruela-Arispe M., Nih L., Kubis N., Henrion D., Loufrani L., Todiras M., Schleifenbaum J., Gollasch M., Zhuang Z., Simons M., Eichmann A., and Le Noble F. (2013) Development 140, 1720-9 |
| ° | miR-30a regulates endothelial tip cell formation and arteriolar branching Jiang Q, Lagos-Quintana M, Liu D, Shi Y, Helker C, Herzog W, le Noble F. (2013) Hypertension 62, 592-8 |
| ° | Inhibition of Notch signaling induces extensive intussusceptive neo-angiogenesis by recruitment of mononuclear cells Dimova I., Hlushchuk R., Makanya A., Styp-Rekowska B., Ceausu A., Flueckiger S., Lang S., Semela D., Le Noble F., Chatterjee S., and Djonov V. (2013). Angiogenesis 16, 921-37 |
| ° | Stimulated Emission Depletion-Based Raster Image Correlation Spectroscopy (STED-RICS) – A Versatile Method for Studying Biomolecular Dynamics in Live Cells. Hedde, P.N., Dörlich, R.M., Blomley, R., Gradl, D., Oppong, E., Cato, A.C.B. and Nienhaus, G.U. (2013) Nature Comm. Jun 27;4:2093. |
| ° | Rediscovering the Double Friedel-Crafts Acylation: An Expedient Entry to Phenanthrene-9,10-diones Crosta, N., Müller, S., Gradl, D., Masters, K.-S. and Bräse, S. (2013) Synlett 24(8): 951-954. DOI: 10.1055/s-0032-1318481. |
| ° | The vestibuloocular reflex of tadpoles (Xenopus laevis) after knock-down of the isthmus related transcription factor XTcf-4 Horn, E.R., El-Yamany, N.A. and Gradl, D. (2013) J Exp Biol.216(Pt 4), 733-741. |
| ° | Synthesis of novel inhibitors blocking Wnt signaling downstream of b-Catenin Halbedl, S., Kratzer, M.-C. Rahm, K., Crosta, N. Masters, K.-C. Zippert, J., Bräse, S. and Gradl, D. (2013) FEBS Lett. 2013 Mar 1;587(5):522-7. doi: 10.1016/j.febslet.2013.01.034. Epub 2013 Jan 25. |
2012
| ° | Extrinsic Notch ligand Delta-like 1 regulates tip cell selection and vascular branching morphogenesis Napp, L.C., Augustynik, M., Paesler, F., Krishnasamy, K., Woiterski, J., Limbourg, A., Bauersachs, J., Drexler, H., Le Noble, F., Limbourg, F.P. (2012). Circulation Research 110, 530-5 |
| ° | Microfluidic polycarbonate chip for long-term cell analyses Kreppenhofer K, Kim C, Schneider M, Herrmann D, Ahrens R, Kashef J, Gradl D, Wedlich D, Guber A. (2012) Biomed Tech (Berl). 2012 Aug 30. doi:pii: /j/bmte.2012.57.issue-s1-E/bmt-2012-4429/bmt-2012-4429.xml. 10.1515/bmt-2012-4429. [Epub ahead of print] |
| ° | Diffusion- and convection-based activation of Wnt/β-catenin signaling in a gradient generating microfluidic chip Kim, C., Kreppenhofer, K., Kashef, J., Gradl, D., Herrmann, D., Schneider, M., Ahrens, R., Guber, A. and Wedlich, D. (2012) Lab Chip. 2012 Dec 21;12(24):5186-5194. doi: 10.1039/c2lc40172j. |
| ° | Subfunctionalization and neofunctionalization of vertebrate Lef/Tcf transcription factors Klingel, S., Morath, I., Strietz, J., Menzel, K., Holstein, T.W., Gradl, D. (2012) Dev Biol. 2012 Aug 1;368(1):44-53. doi: 10.1016/j.ydbio.2012.05.012. Epub 2012 May 26. |
| ° | Live imaging of active fluorophore labelled Wnt proteins Holzer, T., Liffers, K., Rahm, K., Trageser, B., Ozbek, S., Gradl, D. (2012) FEBS Lett. 2012 Jun 4;586(11):1638-44. doi: 10.1016/j.febslet.2012.04.035. Epub 2012 Apr 26. |
| ° | A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice Waaler, J., Machon, O., Tumova, L., Dinh, H., Korinek, V., Wilson, S.R., Paulsen, J.E., Pedersen, N.M., Eide, T.J., Machonova, O., Gradl, D., Voronkov, A., von Kries, J.P., Krauss, S. (2012) Cancer Res. 2012 Jun 1;72(11):2822-32. doi: 10.1158/0008-5472.CAN-11-3336. Epub 2012 Mar 22. |
2011
| ° | Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo Krueger, J., Liu, D., Scholz, K., Zimmer, A., Shi, Y., Klein, C., Siekmann, A., Schulte-Merker, S., Cudmore, M., Ahmed, A., and Le Noble, F. (2011). Development 138, 2111-2120 |
| ° | Arteriogenesis Is Modulated By Bradykinin Receptor Signaling Hillmeister, P.*, Gatzke, N.*, Dulsner, A., Bader, M., Schadock, I., Hoefer, I., Hamann, I., Infante-Duarte, C., Jung, G., Troidl, K., Urban, D., Stawowy, P., Frentsch, M., Li, M., Nagorka, S., Wang, H., Shi, Y., Le Noble, F*., and Buschmann, I*. (2011). Circulation Research 109, 524-533. *equal contribution |
| ° | Neuron navigator 3a regulates liver organogenesis during zebrafish embryogenesis Klein, C., Mikutta, J., Krueger, J., Scholz, K., Brinkmann, J., Liu, D., Veerkamp, J., Siegel, D., Abdelilah-Seyfried, S., and Le Noble, F. (2011) Development 138, 1935-1945 |
| ° | The role of blood flow and microRNAs in blood vessel development Liu, D., Krueger, J., and Le Noble, F. (2011) International Journal of Developmental Biology 55, 419-429 |
| ° | Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling Doubravska L, Krausova M, Gradl D, Vojtechova M, Tumova L, Lukas J, Valenta T, Pospichalova V, Fafilek B, Plachy J, Sebesta O, Korinek V. (2011) Cell Signal. 2011 May;23(5):837-48. doi: 10.1016/j.cellsig.2011.01.007. Epub 2011 Jan 16. |
| ° | Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth Waaler, J., Machon O., von Kries, JP., Wilson, SR., Lundenes, E., Wedlich, D., Gradl, D., Paulsen, JE., Machonova, O., Dembinski, JL., Dinh, H., Krauss, S. (2011) Cancer Res. 2011 Jan 1;71(1):197-205 |
2010
| ° |
Pulsatile shear and Gja5 modulate arterial identity and remodeling events during flow-driven arteriogenesis |
| ° | Fetal growth restriction results in remodeled and less efficient hearts in children Crispi, F., Bijnens, B., Figueras, F., Bartrons, J., Eixarch, E., Le Noble, F., Ahmed, A., and Gratacos, E. (2010) Circulation 121, 2427-2436 |
| ° | En2. Pax2/5 and Tcf-4 transcription factors cooperate in patterning the Xenopus brain Koenig, S.F., Brentle, S., Hamdi, K., Fichtner, D., Wedlich, D. and Gradl, D. (2010) Dev. Biol. 340, 318-328. |
| ° | The shunt problem: control of functional shunting in normal and tumour vasculature Pries, A., Höpfner, M., le Noble, F., Dewhirst, M. W., Secomb, T. W. (2010) Nat Rev Cancer. 2010 Aug; 10(8): 587–59. |