Die Forschung - Research
|Vascular network remodeling and the formation of new blood vessels (angiogenesis and arteriogenesis) plays an important role in the pathophysiology of ischemic cardiovascular disease, diabetes, hypertension, and cancer, which are the most common causes of mortality in western society. In the pediatric setting, improper vascular network remodeling during embryogenesis is a major cause of birth defects, and programs for cardiovascular disease in the adult. Formation of vascular and neuronal networks shows many similarities including common molecular cues and the principle of directed guidance. Factors originally reported to act as guidance factor in the nervous system, also mediate angiogenic remodeling events, and angiogenic factors like VEGF, affect neurogenesis. Furthermore, the patterning of blood vessels and nerves is interdependent, involving signals provided by nerves.
Our goal is to generate novel genetic insights in the regulation of vascular development and arterial-venous vessel identity that can translate into therapeutic strategies. Our research projects aim at understanding the molecular regulation of angiogenesis and arteriogenesis.
1. Neuro-vascular cross-talk and targeting of neuro-degenerative diseases: direct link
2. Vascular remodelling - Angiogenesis and Arteriogenesis - in ischemic cardiovascular diseases: direct link
3. Angiocrine control of tissue regeneration: direct link
4. EC cell-type specific metabolic demands: direct link