Zell- und Entwicklungsbiologie

Publications


2020
The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models.
Klems, A.; van Rijssel, J.; Ramms, A. S.; Wild, R.; Hammer, J.; Merkel, M.; Derenbach, L.; Préau, L.; Hinkel, R.; Suarez-Martinez, I.; Schulte-Merker, S.; Vidal, R.; Sauer, S.; Kivelä, R.; Alitalo, K.; Kupatt, C.; van Buul, J. D.; le Noble, F.
2020. Nature Communications, 11 (1), Art.-Nr. 5319. doi:10.1038/s41467-020-19008-0
Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function.
Stanicek, L.; Lozano-Vidal, N.; Bink, D. I.; Hooglugt, A.; Yao, W.; Wittig, I.; van Rijssel, J.; van Buul, J. D.; van Bergen, A.; Klems, A.; Ramms, A. S.; Le Noble, F.; Hofmann, P.; Szulcek, R.; Wang, S.; Offermanns, S.; Ercanoglu, M. S.; Kwon, H.-B.; Stainier, D.; Huveneers, S.; Kurian, L.; Dimmeler, S.; Boon, R. A.
2020. Communications biology, 3 (1), Art.Nr. 265. doi:10.1038/s42003-020-0987-0
Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis.
Wang, G.; Muhl, L.; Padberg, Y.; Dupont, L.; Peterson-Maduro, J.; Stehling, M.; Noble, F. le; Colige, A.; Betsholtz, C.; Schulte-Merker, S.; Impel, A. van.
2020. Nature Communications, 11 (1), Art. Nr.: 2724. doi:10.1038/s41467-020-16552-7
2019
Requirement of β1 integrin for endothelium-dependent vasodilation and collateral formation in hindlimb ischemia.
Henning, C.; Branopolski, A.; Schuler, D.; Dimitroulis, D.; Huelsemann, P.; Nicolaus, C.; Sansone, R.; Ludolf Postma, J.; Eberhard, D.; Le Noble, F.; Kelm, M.; Lammert, E.; Heiss, C.
2019. Scientific reports, 9 (1), Article no: 16931. doi:10.1038/s41598-019-53137-x
Lef1 regulates caveolin expression and caveolin dependent endocytosis, a process necessary for Wnt5a/Ror2 signaling during Xenopus gastrulation.
Puzik, K.; Tonnier, V.; Opper, I.; Eckert, A.; Zhou, L.; Kratzer, M.-C.; Noble, F.; Nienhaus, G. U.; Gradl, D.
2019. Scientific reports, 9 (1), Article No.15645. doi:10.1038/s41598-019-52218-1
Genetic compensation by epob in pronephros development in epoa mutant zebrafish.
She, J.; Wu, Y.; Lou, B.; Lodd, E.; Klems, A.; Schmoehl, F.; Yuan, Z.; Noble, F. L.; Kroll, J.
2019. Cell cycle, 18 (20), 2683–2696. doi:10.1080/15384101.2019.1656019
Role of Ryanodine Type 2 Receptors in Elementary Ca Signaling in Arteries and Vascular Adaptive Responses.
Kaßmann, M.; Szijártó, I. A.; García-Prieto, C. F.; Fan, G.; Schleifenbaum, J.; Anistan, Y.-M.; Tabeling, C.; Shi, Y.; Noble, F. le; Witzenrath, M.; Huang, Y.; Markó, L.; Nelson, M. T.; Gollasch, M.
2019. Journal of the American Heart Association, 8 (9), e010090. doi:10.1161/JAHA.118.010090
2018
Cardiovascular drugs attenuated myocardial resistance against ischaemia-induced and reperfusion-induced injury in a rat model of repetitive occlusion.
Gatzke, N.; Güc, N.; Hillmeister, P.; Dülsner, A.; Le Noble, F.; Buschmann, E. E.; Ingwersen, M.; Bramlage, P.; Buschmann, I. R.
2018. Open Heart, 5 (2), e000889. doi:10.1136/openhrt-2018-000889
Steerable Induction of the Thymosin β4/MRTF-A Pathway via AAV-Based Overexpression Induces Therapeutic Neovascularization.
Ziegler, T.; Kraus, M.; Husada, W.; Gesenhues, F.; Jiang, Q.; Pinkenburg, O.; Trenkwalder, T.; Laugwitz, K.-L.; le Noble, F.; Weber, C.; Kupatt, C.; Hinkel, R.
2018. Human gene therapy, 29 (12), 1407–1415. doi:10.1089/hum.2017.013
2017
Thymosin β 4 Improves Differentiation and Vascularization of EHTs.
Ziegler, T.; Hinkel, R.; Stöhr, A.; Eschenhagen, T.; Laugwitz, K.-L.; Le Noble, F.; David, R.; Hansen, A.; Kupatt, C.
2017. Stem cells international, 2017, Art. Nr.: 6848271. doi:10.1155/2017/6848271
Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization.
Wild, R.; Klems, A.; Takamiya, M.; Hayashi, Y.; Strähle, U.; Ando, K.; Mochizuki, N.; van Impel, A.; Schulte-Merker, S.; Krueger, J.; Preau, L.; le Noble, F.
2017. Nature Communications, 8, 13991. doi:10.1038/ncomms13991