Abteilungsleitung

Prof. Dr. Ferdinand le Noble


Ferdinand le Noble obtained his PhD at the Cardiovascular Research Institute Maastricht (CARIM) with a thesis addressing the role of angiogenesis in the ontogenesis of essential hypertension.


He focused at understanding how genetic and hemodynamic factors control arterial architecture during development, and identified a critical role for the Vegf-sFlt1-Kdr pathway in fetal programming of adult cardiovascular disease including left ventricular cardiomyopathy and hypertension.

 

After working at the College de France in Paris in the lab of Anne Eichmann and Pierre Corvol, and as Univ. Prof. at the Max Delbrueck Center (MDC) in collaboration with the Center for Stroke Research at the Charite in Berlin, he was appointed full professor (W3) at the Karlsruhe Institute of Technology (KIT).
 


Vascular network remodeling and the formation of new blood vessels (angiogenesis and arteriogenesis) plays an important role in the pathophysiology of ischemic cardiovascular disease, diabetes, hypertension, which are the most common causes of mortality in western society.

Our goal is to generate novel genetic insights in the regulation of vascular development that can translate into therapeutic strategies.

Our research projects aim at understanding the molecular regulation of angiogenesis, arteriogenesis and the formation of organo-typical vasculatures and angiocrine control in the context of neural and cardiac tissue regeneration.

We have a particular interest in the cross-talk between vessels and nerves, and the role of neuronal guidance molecules herein. For this purpose we use an integrative genetic and physiological approach in zebrafish and mouse model systems.

Ferdinand le Noble
Video Interview with Prof. Dr. Ferdinand le Noble (Helmholtz & Friends)


Research Papers
°  The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models.
Klems A, van Rijssel J, Ramms AS, Wild R, Hammer J, Merkel M, Derenbach L, Préau L, Hinkel R, Suarez-Martinez I, Schulte-Merker S, Vidal R, Sauer S, Kivelä R, Alitalo K, Kupatt C, van Buul JD, le Noble F.
Nature Communications 2020 Oct 21;11(1):5319.
doi: 10.1038/s41467-020-19008-0. PMID: 33087700; PMCID: PMC7578835.
°  Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis
Wang G, Muhl L, Padberg Y, Dupont L, Peterson-Maduro J, Stehling M, le Noble F, Colige A, Betsholtz C, Schulte-Merker S, van Impel A
Nature Communications 2020 Jun 1;11(1):2724.
doi: 10.1038/s41467-020-16552-7. PMID: 32483144; PMCID: PMC7264274.
°  Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization.
Wild R, Klems A, Takamiya M, Hayashi Y, Strähle U, Ando K, Mochizuki N, van Impel A, Schulte-Merker S, Krueger J, Preau L, le Noble F
Nature Communications 2017 Jan 10;8:13991.
doi: 10.1038/ncomms13991. PMID: 28071661; PMCID: PMC5234075
°  Circular RNAs are a large class of animal RNAs with regulatory potency
Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N
Nature. 2013 Mar 21;495(7441):333-8.
doi: 10.1038/nature11928. Epub 2013 Feb 27. PMID: 23446348.
   
Reviews
°  VEGF (Vascular Endothelial Growth Factor) Inhibition and Hypertension: Does Microvascular Rarefaction Play a Role?
le Noble FAC, Mourad JJ, Levy BI, Struijker-Boudier HAJ.
Hypertension. 2023 Feb 7.
doi: 10.1161/HYPERTENSIONAHA.122.19427. PMID: 36748474.
°  Interdependence of Angiogenesis and Arteriogenesis in Development and Disease.
le Noble F, Kupatt C
Int J Mol Sci. 2022 Mar 31;23(7):3879.
doi: 10.3390/ijms23073879. PMID: 35409246; PMCID: PMC8999596.


In Cooperation with 
Interaktionen an der Neurovaskulären Schnittstelle
Mitglied der Führungs-Community
Erforschung, Prävention, Diagnostik und Therapie von Herz-Kreislauf-Erkrankungen
Function and pathology of blood vessels
Deutsche Herz-Kreislauf-Forscher
Herz- und Kreislaufforschun
Physiologie in Forschung und Unterricht